Published: Sat, October 06, 2018
Science | By Cecil Little

Trio awarded Nobel Prize for Chemistry

Trio awarded Nobel Prize for Chemistry

Smith created a process that helped develop new drugs that are now being used to treat cancer, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Humira, or adalimumab, was the first drug based on Winter's work to win regulatory approval in 2002.

"This year's prize is harnessing the power of evolution". I smile recalling that, but up to that point she had been trying to modify enzymes (proteins that do chemistry) by thinking carefully about the effects certain changes to their amino-acid sequences ought to have.

Oliver Jones, a chemist at RMIT University in Melbourne, Australia, said in a statement distributed by the U.K. Science Media Center.

Other antibody drugs at the cutting edge of medicine use the same technology, including a number of treatments that have proved highly effective against cancer. Her work has even enabled the creation of enzymes that can carry out reactions and form bonds unknown in biological organisms.

Prof Smith developed the technique of phage display later adopted by Sir Gregory.

After learning that he had won the Nobel Prize, Smith spoke to the Associated Press.

He concludes, "Very few research breakthroughs are novel".

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He built up a collection of phages, with billions of antibody varieties on their surface, and engineered them make them more effective.

"That was certainly the case with my work".

And a lot of winners have also worked in the border of chemistry and biology, like the winners this year.

Two of the three winners of this year's Nobel Prize in Chemistry have virtually polar opposite political connections to Israel: One is actively anti-Israel, while the other promotes ties between Israel and the UK.

She learned she had won when she was "unceremoniously woken up" at 4 her hotel room in Dallas.

She was asleep in a hotel room in Texas when the phone rang.

"I would say the day has been turned upside down", said Smith, who retired in 2015 from the University of Missouri.

Sir Gregory, the Master of Trinity College, Cambridge, has followed a research career based nearly entirely in Cambridge at the Medical Research Council's Laboratory of Molecular Biology and the Centre for Protein Engineering.

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"This operator had a Swedish accent", he told a news conference. "It reminded me of my bank ringing up and telling me I had some dodgy transaction on my account ..."

There will be another party shortly in Cambridge.

MARTIN: NPR's Nell Greenfieldboyce is here to tell us about the winners. They have used the molecular understanding that we today have of the evolutionary process and re-created the process in their laboratories in their test tubes....

Why is the work important? Sir Gregory P. Winter was born in 1951 in Leicester, in the United Kingdom.

Dorhout, who's also an administrator at Kansas State University, said the science disciplines still haven't broadened participation enough to represent society as a whole, and have not always welcomed or recognized female contributions. The Nobel Memorial Prize in Economic Sciences, honouring the man who endowed the five Nobel Prizes, will be revealed on October 8.

The victor of the Nobel Peace Prize is to be announced Friday and the Nobel Memorial Prize in Economic Sciences will be revealed Monday. 8 October in Stockholm will name the victor of the prize for Economics in memory of Alfred Nobel.

For the first time since 1949, the Swedish Academy has postponed the announcement of the 2018 Nobel Literature Prize until next year, amid a #MeToo scandal and bitter internal dispute that has prevented it from functioning properly.

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